ISO/TR 16178-2012 pdf free.Footwear – Critical substances potentially present in footwear and footwear components. This Technical Report describes the critical chemical substances, their potential risks, the materials in which they can be found and the test method(s) which can be used to quantify them. It does not include requirements; it is the responsibility of the user of this Technical Report to fix his/her level of acceptance, for instance using a defined concentration or detection limit or quantification limit. NOTE The proposed test methods indicate the state of the art. Some substances do not include a test method, as no test method is available at the time of publication of this Technical Report. If possible, it is intended to include a test method in a revision of this Technical Report. This Technical Report applies to any kind of footwear and footwear components. 2 Terms and definitions For the purposes of this document, the following terms and definitions apply. 2.1 allergen substance that Is capable of inducing an allergic reaction 2.2 allergy immunologically mediated response to certain specific substances NOTE 1 The specific substances are allergens. NOTE 2 Type-i allergy (respiratory allergy) is mediated by lgE antibodies and can cause asthma, rhinitis…